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The necessarily mean constant-state quantity of distribution documented for sildenafil is approximately one zero five L - a price which suggests the medication undergoes distribution into the tissues .
The protection and efficacy of sildenafil for your treatment of PAH in little ones underneath one yr of age has not been set up as no information is available .
Warning must in the long run be exercised when sildenafil is administered to nursing Ladies as It's not recognised if sildenafil or its metabolites are excreted in human breast milk .
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It is usually observed that sildenafil and its key circulating N-desmethyl metabolite are the two estimated to generally be about 96% bound to plasma proteins . Yet, it has been identified that protein binding for sildenafil is impartial of overall drug concentrations .
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